Sustanon 250 reviews have a beneficial effect on inflammatory and degenerative diseases of the nerves and the skeletal system. Contribute to increased blood flow, and improve the functioning of the nervous system. Thiamine plays a key role in the metabolism of carbohydrates, and in the Krebs cycle with subsequent participation in the synthesis of TPP (thiamine pyrophosphate), and ATP (adenosine triphosphate). Pyridoxine is involved in the metabolism of protein, and in part in the metabolism of carbohydrates and fats. The physiological function of both vitamins is a potentiation of each other, which manifests itself in a positive impact on the nervous, neuromuscular and cardiovascular systems. At deficiency of vitamin Wb widespread deficiency state quickly cease after the introduction of these vitamins. Cyanocobalamin is involved in the synthesis of the myelin sheath, it stimulates hematopoiesis, reduces the pain associated with a lesion of the peripheral nervous system, stimulates the exchange of nucleic acid through a folic acid activation. Lidocaine -mestnoanesteziruyuschee means for causing all kinds of local anesthesia: terminal, infiltration, and conductors.
After intramuscular thiamine is rapidly absorbed from the injection site and enters the blood (484 ng / ml after 15 minutes on the first day of dosing with 50 mg) and unevenly distributed in the body when its content in leukocytes of 15% red blood cells of 75% and plasma 10%. In the absence of significant reserves in the body of vitamin, it must be ingested daily. Thiamine penetrates the blood-brain and placental barriers and is found in breast milk. Thiamine is excreted in the urine through the alpha phase of 0.15 hours, the beta phase – after 1 hour in the terminal phase – for 2 days. The major metabolites are tiaminkarbonovaya acid Pyramin and some unidentified metabolites. Of sustanon 250 reviews all the vitamins thiamine stored in the body in the smallest amounts. An adult human contains about 30 mg of thiamine as thiamine pyrophosphate, 80%, 10% thiamine triphosphate and the remaining amount as thiamine monophosphate. After intramuscular injection of pyridoxine is rapidly absorbed into the bloodstream and distributed in the body, acting as a coenzyme after phosphorylation group CH 2 OH in the 5th position. About 80% of vitamin binds to plasma proteins. Pyridoxine is distributed throughout the body and crosses the placenta and is found in human milk, is deposited in the liver and is oxidized to 4-pyridoxine acid, which is excreted in the urine, a maximum 2-5 hours after absorption. The human body contains 40-150 mg of vitamin Wb and its daily elimination rate of approximately 1,7-3,6 mg at 2.2-2.4% fill rate.
As a pathogenetic and symptomatic treatment in the complex therapy of diseases and syndromes of the nervous system of various origins: neuralgia, neuritis, facial nerve paresis, optic neuritis, ganglionitis (including herpes zoster), plexopathy, neuropathy, polyneuropathy (diabetic, alcohol, etc..) nocturnal muscle cramps, particularly in older age groups, the neurological manifestations of osteochondrosis: radiculopathy, lumbar ischialgia, muscular-tonic syndromes.
Pregnancy and breast-feeding ( see. Section “Use in <pregnancy and breastfeeding period” ).
Decompensated heart failure.
Increased individual sensitivity to the drug.
Pregnancy and lactation:
use of the drug is contraindicated ‘during pregnancy and breast-feeding ( see “Contraindications” section. ).
Dosing and Administration
Injection is performed by deep intramuscular injection.
In cases of severe pain syndrome for the rapid achievement of a high level of drug in the blood, it is advisable to start treatment with 2.0 ml daily for 5-10 days. Subsequently, after decrease pain and mild forms of disease or transferred further to therapy dosage form for oral administration (e.g., a drug kompozitum) or on rarer injection (2-3 times per week for 2-3 weeks) with the possible continuation of therapy dosage form for oral administration
(eg, drug sustanon 250 reviews compositum). Recommended weekly monitoring by a physician therapy.
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