Some of the following microorganisms showed resistance to minocycline, so it is advisable to conduct laboratory susceptibility testing prior to use. Antibiotics tetracycline is not recommended for the treatment of streptococcal and staphylococcal sustanon 250 side effects infections, if not shown the sensitivity of microorganisms to minocycline.
- Bacillus anthracis
- Listeria monocytogenes
- Staphylococcus aureus
- Streptococcus pneumoniae
- Bartonella bacilliformis
- Brucella species
- Calymmatobacterium granulomatis
- Campylobacter fetus
- Francisella tularensis
- Haemophilus ducreyi
- Vibrio cholerae
- Yersinia pestis
For the following microorganisms is strongly recommended that a sensitivity study to minocycline:
- Acinetobacter species
- Enterobacter aerogenes
- Escherichia coli
- Haemophilus influenzae
- Klebsiella species
- Neisseria gonorrhoeae *
- Neisseria meningitidis *
- Shigella species
- Actinomyces species
- Borrelia recurrentis
- Chlamydia psittaci
- Chlamydia trachomatis
- Clostridium species
- Entamoeba species
- Fusobacterium nucleatum subspecies fusiforme
- Mycobacterium marinum
- Mycoplasma pneumoniae
- Propionibacterium acnes
- Treponema pallidum subspecies pallidum
- Treponema pallidum subspecies pertenue
- Ureaplasma urealyticum
The volume of distribution is 0.7 l / kg. Minocycline is well into the organs and tissues: 30 – 45 minutes after ingestion found in therapeutic concentrations in the kidneys, spleen, eye tissues, pleural and ascites fluid, synovial exudate, exudate maxillary and frontal sinuses, in the liquid sulcus. It penetrates sustanon 250 side effects into cerebrospinal fluid (20 – 25% of the level determined in plasma). It passes through the placenta, enters the mother’s milk.
Repeated administration of the drug may accumulate. It is accumulating in the reticuloendothelial system and bone. The bones and teeth forms insoluble complexes with Ca 2+ . Treated kishechnopechёnochnoy recycling 30-60% of the dose is excreted in the intestinal contents; 30% excreted by the kidneys within 72 hours (of which 20-30% – in an unmodified form), with severe chronic renal failure – only 1-5%. The half-life (the T 1/2 ) Minocycline is approximately 16 hours.
Indications for use:
Minocycline hydrochloride is used to treat the following diseases sensitivity provided pathogens:
- skin Infections
- Spotted fever, typhoid fever, typhoid fever, Q fever (koksiellёz), rickettsial disease and vesicular tick fever
- Respiratory Tract Infections
- lymphogranuloma venereum
- parrot disease
- Trachoma (infectious keratoconjunctivitis)
- Conjunctivitis with inclusions (paratrahoma)
- NGU, an infection of the cervical canal and the anus in adults
- Cyclic fever
- Inguinal granuloma
- Yaws (tropical sustanon 250 side effects granuloma, non-venereal syphilis)
- Vincent’s infection
In the case of acute intestinal amebiasis allowed the use of minocycline as an adjunct to amebitsidnym drugs.
In severe acne, minocycline may be used as adjunctive therapy.
Oral administration of minocycline is indicated for asymptomatic carriers of Neisseria meningitidis to eradicate meningococci from the nasopharynx.
To prevent the emergence of resistance it is recommended the use of minocycline in accordance with the results of laboratory tests, including serotyping and susceptibility of pathogens. For the same reason it is not recommended the use of minocycline as a preventive measure in case of high risk of meningococcal meningitis.
Oral administration of minocycline is not recommended for the treatment of meningococcal infections.
Experience of clinical application of minocycline shows efficacy in the treatment of infections of sustanon 250 side effects marinum, however, currently this data is not confirmed by the results of controlled clinical trials.
- Hypersensitivity to minocycline, tetracycline and other ingredients
- Severe hepatic and renal failure
- Systemic lupus erythematosus
- Children under 8 years (the period of tooth development)
- Simultaneous treatment with isotretinoin
- Lactase deficiency, lactose intolerance, glucose-galactose malabsorption
Violations of the liver and kidney, the simultaneous application of hepatotoxic drugs.
Dosage and administration:
Inside, after a meal. It is recommended to drink plenty of fluids (milk can) to reduce the risk of irritation and ulceration of the esophagus.
Initial dose sustanon 250 side effects mg (2 capsules of 100 mg or 4 capsules of 50 mg), after taking 100 mg (1 capsule of 100 mg or 2 capsules of 50 mg) every 12 hours (twice daily) .
The maximum daily dose should not exceed 400 mg.
Infections of the urinary and anogenital caused by Chlamydia and Ureaplasma: 100 mg (one 100 mg capsule or two capsules of 50 mg) every 12 hours for 7-10 days.
Inflammatory diseases of the pelvic organs in women in the acute stage of 100 mg (one 100 mg capsule or two capsules of 50 mg) every 12 hours, sometimes in combination with cephalosporins.
Primary syphilis in patients hypersensitive to penicillin 100 mg (one 100 mg capsule or two capsules of 50 mg) twice a day for 10-15 days.
Gonorrhea: 100 mg (one 100 mg capsule or two capsules of 50 mg) twice a day for 4-5 days, or 300 mg single dose.
Uncomplicated gonococcal infections (excluding urethritis and anorectal infection) in man: an initial dose – 200 mg (2 capsules of 100 mg or 4 capsules of 50 mg), which supports – 100 mg (1 capsule of 100 mg or 2 capsules of 50 mg) by every 12 hours for at least 4 days, followed by microbiological assessment of recovery after 2-3 days after discontinuation of the drug.
Uncomplicated gonococcal urethritis in men: 100 mg (one 100 mg capsule or two capsules of 50 mg) every 12 hours for 5 days.
Acne: 50 mg (1 capsule 50 mg) per day, duration of the course of 6-12 weeks.
On the background of the drug, due antianabolicheskogo effect inherent drugs tetracycline group, increase urea levels in the blood plasma can occur. In patients with normal renal function, it does not require discontinuation of therapy. In patients with severe renal impairment may occur azotemia develop, hyperphosphatemia, and acidosis. In this situation it is necessary to monitor the level of urea and creatinine in the blood plasma, and the maximum daily dose of minocycline should not exceed 200 mg.
Pharmacokinetics of minocycline in patients with renal failure (creatinine clearance less than 80 mL / min) at present poorly understood, in order to infer the need for dose adjustment.
If hepatic dysfunction sustanon 250 side effects drug be used with caution. Children older than 8 years in infections caused by pathogens sensitive to minocycline: initial dose – 4 mg / kg followed by 2 mg / kg every 12 hours.