Meldonium is a precursor of carnitine, a structural analog of gamma-butyrobetaine sustanon 250, a substance that is in every cell of the human body.
In high load conditions meldonium restores the balance between delivery and cellular oxygen demand, eliminating the accumulation of toxic products of metabolism in the cells, protecting them from damage; also has a tonic effect. As a result of its use increases the body’s resistance to stress and ability to quickly restore energy reserves.
The drug has a stimulating effect on the central nervous system (CNS) – increase of motor activity and physical stamina. Because of these properties use including to enhance physical and mental performance.
After oral administration, the drug is rapidly absorbed, bioavailability – 78 .% Maximum concentration (the C max ) in plasma is achieved in 1-2 hours after ingestion. It is metabolized in the body mainly in the liver with the formation of two major metabolites are excreted by the kidneys. The half-life (T 1 / 2 ) when administered depends on the dose, it is 6.3 hours.
Health and sustanon 250 in pregnant women has not been studied, therefore, in order to avoid possible adverse effects on the fetus, use of the drug is contraindicated in pregnant women.
Withdrawal of milk and effects on the health of the newborn have not been studied, therefore, if necessary, the drug should stop breastfeeding.
The daily dose for adults is 500 mg (2 capsules). All dose used in the morning at one time or dividing it into 2 doses.
The course of treatment -. 10-14 days
if necessary, repeat the treatment after 2-3 weeks.
In connection with a possible stimulating effect of the drug is recommended in the morning.
Meldonium usually well tolerated. . However, in susceptible patients, as well as in cases of exceeding the recommended dose may cause adverse reactions
Adverse drug reactions are grouped by system-organ classes according to the following gradation frequency: very common (> 1/10), common (> 1/100 and < 1/10), uncommon (> 1/1000 and <1/100), rarely (> 1/10 000 and <1/1000) and very rare (<1/10 000), the frequency is not known – according to available data to estimate the frequency impossible.
From the blood and lymphatic system
Frequency unknown: eosinophilia.
On the part of the immune system
Common: allergic reactions (redness, rash, itching, swelling).
With the side of the heart
Very rare: tachycardia.
From the side of blood vessels
Very rare: decrease in blood pressure.
On the part of the gastrointestinal tract Common: dyspepsia
From the nervous system Common: headache;
Frequency unknown: excitement.
Frequency unknown: weakness.
If any of thesesustanon 250 instructions side effects are compounded, or if you notice any other side effects not mentioned in the instructions, inform your doctor.
No cases of overdose were reported meldonium. The drug has low toxicity and does not cause severe adverse reactions.
Symptoms: lowering blood pressure, accompanied by headache, tachycardia, dizziness and general weakness.
Treatment : symptomatic.
In severe overdose need to monitor liver and kidney function.
Meldonium allowed simultaneously used with long-acting nitrates, and other antianginal drugs, cardiac glycosides and diuretics. It can also be combined with anticoagulants, antiplatelet agents, antiarrhythmic drugs and other drugs that improve the microcirculation.
Meldonium may increase the effects of nitroglycerin, nifedipine, beta-blockers, other antihypertensive agents and peripheral vasodilators. The simultaneous use of the drug with other drugs meldonium is not allowed because it can increase the risk of adverse reactions.
Patients with chronic diseases of the liver and kidneys should be careful with long-term use of the drug. If necessary, long-term (over a month) use of the drug should consult with a specialist. anabolic steroids online shop
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