As a result of its use of the body acquires the ability to withstand stress and to quickly restore energy reserves. Because of these properties sustanon 300 is used to treat a variety of disorders of the cardiovascular system, the blood supply to the brain, as well as to improve physical and mental performance. As a result of reducing the concentration of carnitine is synthesized hard gamma-butyrobetaine, which has vasodilating properties. In the case of acute ischemic myocardial injury inhibits the formation of necrotic areas, shorten the rehabilitation period. In heart failure, increases myocardial contractility, increases exercise tolerance, reduces the frequency of angina attacks. In acute and chronic ischemic cerebrovascular disorders improves blood circulation in the ischemic focus, promotes redistribution of blood to the ischemic area.
The drug eliminates functional disturbances of the nervous system in patients with chronic alcoholism in the syndrome of abstinence.
Bioavailability drug after intravenous administration is 100%. The maximum plasma concentration is reached immediately after its introduction. It is metabolized in the body into two major metabolites which the kidneys.
In the treatment of coronary heart disease (angina, myocardial infarction); chronic heart failure and cardiomyopathy dyshormonal, as well as in the treatment of acute and chronic disorders of blood supply to the brain (stroke and cerebrovascular insufficiency). Hemophthalmus and retinal hemorrhages of different etiologies, thrombosis of the central retinal vein and its branches, retinopathy of different etiology (diabetic, hypertensive).
Reduced performance; mental and physical stress (including athletes).
abstinence syndrome in alcoholism (in combination with a specific treatment of alcoholism).
Hypersensitivity to the drug, increased intracranial pressure (in violation of the venous outflow, vnutricheregshyh tumors), age 18 years (effectiveness and safety have not been established), pregnancy, lactation.
Application of pregnancy and during breastfeeding
Health and Safety in pregnant women has not been studied, therefore, in order to avoid possible adverse effects on the fetus, its use is contraindicated. Isolation sustanon 300 milk and its impact on the health of the newborn have not been studied, so, if you must use, should stop breastfeeding.
Dosing and Administration
In view of the possible development of stimulating effect, it is recommended to use in the morning. Mildronat administered intramuscularly (i / m), intravenous (i / v) and parabulbarly.
The route of administration, the dose and duration of treatment is determined individually depending on the indication, the severity of the condition and others. 1. Cardiovascular diseases in the complex therapy:
- coronary heart disease (myocardial infarction) in / jet by 0.5-1.0 g per day applying the entire dose at once or dividing it into 2 of the introduction;
- coronary heart disease (stable angina); congestive heart failure and cardiomyopathy dyshormonal in / jet by 0.5-1.0 g per day (5-10 ml of the, applying the entire dose at once or dividing it into 2 administration, or / m 0.5 g 1-2 times a day, a course of treatment 10-14 days, followed by transfer to a reception inside.
The total course of treatment 4-6 weeks. 2. Cerebrovascular accidents in the complex therapy in the acute phase of 0.5 g 1 time per day / in 10 days, going to the ingestion of 0.5-1 The total course of treatment – 4-6 weeks. In chronic cerebrovascular insufficiency (vascular encephalopathy) 0.5 g sustanon 300in / m or / 1 time a day for 10 days, followed by 0.5 g orally. The total course of treatment -4-6 weeks. Repeated courses (usually 2-3 times a year) are possible after consultation with the doctor. 3. Ophthalmopathology (hemophthalmus and retinal hemorrhages of different etiologies, thrombosis of the central retinal vein and its branches, retinopathy of different etiology (diabetic, hypertensive)). 0.05 g (0.5 ml of the drug parabulbarno within 10 days. Including used in a combination therapy. 4. The mental and physical overload of 0.5 g in / m or / 1 time per day. The course of treatment -10-14 days. If necessary, repeat the treatment after 2-3 weeks. 5. Chronic alcoholism , 0.5 g (5 ml sustanon 300 / m or / in 2 times a day. The course of treatment -7-10 days.
Rarely – allergic reactions (redness, rash, itching, swelling), as well as dyspepsia, tachycardia, decrease or increase in blood pressure, agitation.Very rarely – eosinophilia, general weakness.
Symptoms: lowering blood pressure, accompanied by headache, tachycardia, dizziness and general and does not cause side effects and dangerous to patient health.
Interactions with other drugs
can be combined with antianginal drugs, anticoagulants, antiplatelet agents, antiarrhythmics, diuretics, bronchodilators. Enhances the effect of cardiac glycosides.
In view of the possible development of mild tachycardia and hypotension, caution should be exercised when combined with nitroglycerin, nifedipine, alpha-blockers, other antihypertensive agents and peripheral vasodilators, enhances their effect.
Many years of experience in the treatment of acute myocardial infarction and unstable angina in cardiology departments shows that Mildronat not the drug of I series with acute coronary syndrome and its use is not absolutely necessary.
Effects on ability to drive and use machines
There are no data on the adverse effects of the drug speed of psychomotor reactions.