Test sustanon induces a contraction of smooth muscle fibers of the myometrium and cervical extension. The ability of misoprostol to encourage uterine contractions and cervical ripening facilitates the removal of the uterus. The drug has a weak stimulating effect on the smooth muscles of the gastrointestinal tract. Large doses of misoprostol inhibit gastric acid secretion.Misoprostol has no clinically significant effect on prolactin levels of gonadotropins, thyrotropin, growth hormone, thyroxine, cortisol, creatinine, platelet aggregation, pulmonary function and cardiovascular system.
When administered orally is rapidly absorbed. Simultaneous reception with food – reduces the bioavailability of misoprostol (fatty foods significantly reduces the absorption without affecting the duration of absorption).
The walls of the gastrointestinal tract and the liver is metabolized to a pharmacologically active metabolite of diester – misoprostol acid.
Dose Increase misoprostol 200 mcg to 400 mcg leads to an increase in plasma concentrations of misoprostol acid in 2 times.
Write mainly through the intestine and kidney (less than 1%).
Termination of pregnancy of early terms (up to 42 days of amenorrhea) in combination with mifepristone.
- Hypersensitivity to the drug;
- Cardiovascular diseases;
- Diseases of the liver and kidneys;
- Diseases associated with prostaglandin-dependent, or contraindications to the use of prostaglandins: glaucoma, asthma, hypertension;
- Endocrinology and endocrine diseases, including diabetes mellitus, adrenal dysfunction;
- Gormonalnozavisimyh tumor;
- The use of intrauterine contraceptive (before application is necessary to remove the IUD;
- Suspected ectopic pregnancy.
Use during pregnancy and lactation
The drug can be used only for pregnant her interruption, otherwise it is contraindicated in pregnancy. In establishing pregnancy in patients taking Misoprostol, therapy with this drug should be discontinued.
It is necessary to inform patients about the potential dangers of misoprostol (teratogenic effects).
Breast-feeding should be stopped for 7 days after taking mifepristone in a method of medical abortion (up to 5 days after misoprostol Hour) .
Dosage and administration
for termination of pregnancy test sustanon in conjunction with mifepristone drug should be used in facilities that are appropriately trained medical staff.
Inside, 36-48 hours after ingestion of 600 mg (3 tablets) administered mifepristone 400 mg (2 tablets) of the drug Mirolyut ® .
Cramping abdominal pain, dizziness, headache, nausea, vomiting, flatulence, diarrhea, skin rash, pyrexia.
The recommended dose of misoprostol does not cause adverse reactions on the part of the cardiovascular system, liver or kidneys.
misoprostol toxicity was not found in humans. Clinical signs that may indicate excess dosages are drowsiness, tremor, cramps, abdominal pain, fever, tachycardia, hypotension or bradycardia.
The interaction with other drugs
reception for a long time of rifampicin, isoniazid, anticonvulsants, antidepressants, cimetidine, acetylsalicylic acid, indomethacin and barbiturates, smoking more than 10 cigarettes per day stimulates metabolism misoprostol, reducing its serum levels.
For 1 week after misoprostol should abandon admission of aspirin and other nonsteroidal anti-inflammatory drugs.
In applying for termination of early pregnancy, misoprostol should be used only in combination with mifepristone. In combination with mifepristone, misoprostol should be used only by prescription and under medical supervision and only in specialized hospitals, with capacity to provide emergency surgical gynecological and blood transfusion services.
Use of the drug requires prevention of Rh-conflict and other general activities related to abortion.
Before the appointment of misoprostol patient to be informed in detail about the action and the possible side effects of the drug. The patient should be observed in a medical institution for 4-6 hours prior to taking the drug. During and after taking the drug the patient should be given timely medical assistance in the event of massive bleeding or other complications.
After receiving the drug in patients, as a rule, there is a slight vaginal bleeding, some women have very long. At a very early stage of pregnancy can have an abortion after taking mifepristone, but in this case is also necessary reception of tablets of misoprostol for medical abortion optimization results. After receiving misoprostol in approximately 80% of women have an abortion occurs within 6 hours and approximately 10% of women -. 1 week
Patients should be retested in the same hospital after 8-15 days after taking the drug. If necessary, it should be carried out or ultrasound to determine the level of human chorionic gonadotropin in serum. If you suspect incomplete abortion test sustanon or continuation of the pregnancy is necessary to conduct a comprehensive medical examination in a timely manner.
In case of incomplete abortion or ongoing pregnancy, estimated at 10-14 days after mifepristone necessarily spend vakuumaspiratsiyu with subsequent histological examination of the aspirate, as an evaluation of the impact of the drug on the formation of congenital malformations the development of the fetus. lixus labs